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E to the cell [74]. Once inside, the first step in glycolysis is definitely the irreversible conversion of glucose to glucose 6-phosphate, catalyzed by hexokinases (HKs) I-IV [63, 75, 76]. Specifically, HK-II will be the predominant isoform in insulin-sensitive tissues [76] and may be upregulated up to 100-fold in cancer [75]. Furthermore, HK-II competitively binds towards the voltage-dependent an

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